Archana Bhardwaj - 2022 - Bioinformatics Applications

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2022 - Bioinformatics Applications - Systems Medicine

Special topics course within “Bioinformatics”: Systems Medicine

Location: refer to CELCAT and course administrator

In case the session is online, the following link will be used:
https://global.gotomeeting.com/join/650367333

New to GoToMeeting? Get the app now and be ready when your first meeting starts: https://global.gotomeeting.com/install/650367333

Course schedule changes: via ULg mail

Lecturer: Prof Dr Dr Kristel VAN STEEN

Course themes

I: Genome-wide association studies

Components of GWAS
Case studies via assignment

II: Systems medicine

“Interactions”
- public health
- precision medicine linked to between-patient heterogeneity
Discussions following assignment envisages augmented understanding of:
- Translational aspects of GWAS (how? successful?)
- Individual heterogeneity via “interaction” networks (role of GWAS in such networks?
- Informativity versus redundancy or noise (subnetwork discovery?);
- Multi-view (integration?);
- GWAS for stratified medicine (what about the environment or microbiome?)

Classes

Dates	Themes	GoToMeeting ID (when applicable)	Course materials
March 9 (2-6pm)	I: GWAS	https://global.gotomeeting.com/join/650367333	Course adminstration In-class reading and discussion Course slides: Bioinf applications_2021_course notes_CLASS Theme I
March 23 (2-6pm)	II: Systems Medicine	In person	Course slides: click here
Assignment to find applied GWAS studies: Go to https://www.disgenet.org/ and the SEARCH button Go to “General links” and “Summary of All Variant-Disease Associations” Click on ADD/REMOVE FILTER Type in the DISEASE of your choice (make sure you use the convention suggested by the data bases) Select in addition SOURCE GWASCAT if you wish to have GWAS studies from the GWAS catalogue; alternatively select SOURCE GWASDB Take most recent studies “Last Ref” and/or those with a good number of evidences via “N PMIDs” GO!			Assignment Critical evaluation of a paper
		To prepare (in English)	Evaluated
April 4 (2-6 pm)	III: Presentations with discussions	ONLINE: https://global.gotomeeting.com/join/650367333 1. Select 3 Q to work out in depth on presentation slides. 2. There is no limit on the number of slides but the presentation should be ~15min	Oral slides presentation with Q&A clarity of slides accuracy relevant illustrations (be creative) links to other resources (incl class refs) efforts made to understand concepts/analysis flow
		1. Comprehensive slides deck related to homework assignment. 2. TBD	Written exam: Integration of comprehensive slides deck with additional individual assessment

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