2018 - GBIO0002 - Genetics and bioinformatics

In this course genetic concepts are introduced that are necessary to understand a selection of bioinformatics related data analysis problems. To solve these problems a variety of analytic tools will be explained and exemplified.

The course is in part based on interactive ex-cathedra lectures and in part on interactive practical sessions. The exercise sessions allow students to become familiar with the theoretical concepts introduced during the theory classes. They prepare students to successfully carry out their homework assignments.

This course was organized by Kristel VAN STEEN and Franck DEQUIEDT

The practical sessions were given by Archana BHARDWAJ


Schedule

Start date 18 September 2018
Location Room R.21, B28
Time 14:00-18:00


 

 

Announcement :

5-12-2018 : We have provided Q and A part for Part I. 

7-12-2018 : Mail will be send to all students by Prof Kristel (for HW2 Q and A/ Literature style choice Make sure to check it)

 

Dates Topics Materials
Sep-18           Introduction                           

Course Organization

Course Administration

Lecture 1  

Reference Books

R-cookbook                                  

Sep-25 Genetics and Genetic markers; Variant Calling

Lecture 2 (French version)

Lecture 2-ENG (English version)

 Review_Genetic_variation

  

 



Oct-2




Genetic mapping using GWAS: Why, What, How?

 

   Lecture 3 

   Anderson2010

   Anderson2010_QA

    Bush2012

    Marees2018

    Other class References

 

Oct-9

 
GWAS in practice: focus on GenABEL
     
    (Bring your Laptop)
 
 

Statistical Communication

 GenABEL-tutorial-Chapter5

 Ikegawa2012

  Lecture_2_3

  Barbara2018

  Liang2018

 HW1-PAPERS

 HW1-PART1-PART2:Updated

Reed2015

 
 

 Oct-16

 

Complicating factors in Bionformatics Analytics: Confounders; Sparse Data  
 

   Lecture5

   Thornton-Wells2006

   Astle2009

    Clark2011

   Evangelou2012

 Oct-23

Dealing with complicating factors in practice: focus on confounding

 
    Lecture6
   
     Jack2015

    Patterson2006

 

Oct-30

 

 
 Nov-6 Sequence comparisons: Recognizing Words

    Lecture7


 Nov-13

Principles of sequencing: DNA, RNA

Handling sequence data in practice: focus on alignment

(Bring your Laptop)


  
 

    Lecture8-Session1

    Lecture8-Session2

 Nov-20

Power Failure

 
 Nov-27

Principles of gene expression and proteomics data generation

 
    Lecture9
    
   
  

 Dec-4

RNA-seq analyses in practice: focus on differentation and co-expression
 

Dec-11

HW1 presentations and discussion  

Dec-18

HW2 presentations and discussion + Opportunity for Q&A to exam / Course survey  

                                                Marks

Tasks Points
Homework 1  
Homework 2  
Examination  
Presentation Participation  

 

 Check this : Question format


 

    PLEASE SUBMIT YOUR HOMEWORK at email address a.bhardwaj@uliege.be